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This book is the fifth annual Blue Book to track the situation of innovation and entrepreneurship in Henan province, organized by the Huanghe Science and Technology University, Henan Zhongyuan Innovation and Development Research Institute, Henan Province University Think Tank Association. With the theme of "Innovation and Entrepreneurship drive Employment", the book conducts in-depth research from three aspects：environment，principal players and platform. This book strives to fully, objectively and truthfully reflect the achievements of innovation and entrepreneurship-driven employment in Henan since 2020, provides theoretical and intellectual support for Henan to build a major center for innovation in the central and western China and promote the construction of "four strong provinces" and "happy homeland" under a new development paradigm of a "dual circulation".