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Annual Report on Innovation City Development of Guangzhou（2021），one volume of the Guangzhou Blue Book Series complied by Guangzhou Academy of Social Sciences，is focused on Guangzhou innovation city development. This book is composed of five parts.

Part 1 is the General Report. Based on the connotation of innovative city，it calculates the innovative city index of Guangzhou from 2016 to 2020，combines the findings of the Guangzhou Enterprise Technology Innovation Questionnaire，summarizes the main characteristics and pressure of Guangzhou innovation city development in 2020，analyzes the environment and influencing factors，prospects the trend of Guangzhou innovation city development in 2021. In the end，this report proposes seven countermeasures on promoting Guangzhou innovation city development.

Part 2 is Comprehensive Reports. This part summarizes the main achievements and problems of innovation development in Guangzhou，discusses the construction of innovation service facilities system of China-Singapore Guangzhou Knowledge City，analyzes the main features of financing development of the biomedical industry in Guangzhou，puts forward the main measures to further promote the reform of Guangzhou’s business environment.

Part 3 is Science and Technology Reports. This part explores the main path of scientific and technological innovation development in Guangzhou during the 14th Five Year Plan Period，analyzes the influence of government subsidies on R&D investment of listed enterprises in Guangzhou，shows the situation of R&D activities of enterprises in key industries in Guangzhou，puts forward the main strategies for promoting technological innovation in Guangzhou based on the comparative analysis of PCT patent applications.

Part 4 is Energy Reports. This part summarizes the development trend，analyzes the development basis of Guangzhou，puts forward the related countermeasures and suggestions from integrated energy system，natural gas hydrate industry，biomass energy industry and hydrogen industry.

Part 5 is Case Reports. This part takes enterprises and institutions as the research objects，such as Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences，Guangzhou Institute of Energy Conversion Chinese Academy of Sciences，Guangdong University of Technology，Guangzhou KingMed Diagnostics Group Company Limited. It analyzes the characteristics of innovation development，explores the internal and external factors affecting innovation，and puts forward some countermeasures and suggestions.